Prediksi Toksisitas Ginjal Cabe Jawa (Piper Retrofractum Vahl.) Dengan Metode In Silico

Samsul Hadi; Deni Setiawan; Nazwa  Rahmadina; Rizka Aulia  Ramadani; Kunti Nastiti

doi:10.58794/jfarm.v2i2.1022

Authors

Samsul Hadi Unversitas Lambung Mangkurat
Deni Setiawan Universitas Lambung Mangkurat
Nazwa Rahmadina Universitas Lambung Mangkurat
Rizka Aulia Ramadani Universitas Lambung Mangkurat
Kunti Nastiti Universitas Sari Mulia

DOI:

https://doi.org/10.58794/jfarm.v2i2.1022

Keywords:

P. retrofractum, ginjal, skore docking

Abstract

Cabe Jawa (Piper retrofractum Vahl.) dikenal sebagai bahan baku pembuatan dalam herbal. Dengan manfaat yang begitu luas, diperlukan penelitian mengenai toksisitas P. retrofractum khususnya terhadap ginjal. Tujuan dari penelitian ini adalah melakukan skrining senyawa kimia dari P. retrofractum yang berpotenssi menyebabkan gangguan ginjal. Metode yang digunakan dalam penelitian ini adalah menggunakan docking PLANTS dan bahan yang digunakan dalam penelitian ini diperoleh darai knapsackfamily. Hasil dari penelitian ini diperoleh skore docking masing masing ligand sebagai berikut (+)-Sesamin (-83.8785); L-Sesamin (-85.9199); Guineensine (-104.444); Pipercide (-95.8947); Retrofractamide A (-92.7619); Methyl piperate (-75.2266); 3, 4, 5-Trimethoxy dihydrocinnamic acid (-43.388). Kesimpulan penelitian ini adalah senyawa yang berpotensi dari P.retrofractum yang berpotensi menyebabkan gangguan ginjal adalah Guineensine.

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